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Managing Thyroid Disease During and After Pregnancy: Guidelines

By Mary Shomon, About.com

Updated: March 03, 2009

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Antibodies, Graves' Disease and the Newborn: Guidelines

TSH receptor-stimulating or TSH receptor-binding antibodies in the mother can cross the placenta, and affect the baby’s thyroid. If a woman is positive for these antibodies during pregnancy, her baby can be born with hyperthyroidism. These antibodies should, therefore, be measured in women who have Graves’ disease, or who have had previous newborns who developed Graves’ disease. Treatment of the mother with antithyroid drugs may be necessary to reduce the risk to the newborn.

If a woman with elevated TSH receptor-stimulating or TSH receptor-binding antibodies is treated with antithyroid drugs, fetal ultrasound evaluation should be conducted. This ultrasound should look for evidence of thyroid dysfunction in the developing baby including slow growth and enlarged thyroid, among other signs.

If a new mother has Graves’ disease, her newborn should be evaluated for thyroid dysfunction after birth.

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